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Statistical design and the analysis of gene expression microarray data.

Authors
  • Kerr, M K
  • Churchill, G A
Type
Published Article
Journal
Genetical research
Publication Date
Apr 01, 2001
Volume
77
Issue
2
Pages
123–128
Identifiers
PMID: 11355567
Source
Medline
License
Unknown

Abstract

Gene expression microarrays are an innovative technology with enormous promise to help geneticists explore and understand the genome. Although the potential of this technology has been clearly demonstrated, many important and interesting statistical questions persist. We relate certain features of microarrays to other kinds of experimental data and argue that classical statistical techniques are appropriate and useful. We advocate greater attention to experimental design issues and a more prominent role for the ideas of statistical inference in microarray studies.

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