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Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.

Authors
  • Liedtke, Wolfgang
  • Leman, Elizabeth E
  • Fyffe, Robert E W
  • Raine, Cedric S
  • Schubart, Ulrich K
Type
Published Article
Journal
The American journal of pathology
Publication Date
Feb 01, 2002
Volume
160
Issue
2
Pages
469–480
Identifiers
PMID: 11839567
Source
Medline
License
Unknown

Abstract

Stathmin is a cytosolic protein that binds tubulin and destabilizes cellular microtubules, an activity regulated by phosphorylation. Despite its abundant expression in the developing mammalian nervous system and despite its high degree of evolutionary conservation, stathmin-deficient mice do not exhibit a developmental phenotype.(1) Here we report that aging stathmin(-/-) mice develop an axonopathy of the central and peripheral nervous systems. The pathological hallmark of the early axonal lesions was a highly irregular axoplasm predominantly affecting large, heavily myelinated axons in motor tracts. As the lesions progressed, degeneration of axons, dysmyelination, and an unusual glial reaction were observed. At the functional level, electrophysiology recordings demonstrated a significant reduction of motor nerve conduction velocity in stathmin(-/-) mice. At the molecular level, increased gene expression of SCG 10-like protein, a stathmin-related gene with microtubule destabilizing activity, was detected in the central nervous system of aging stathmin(-/-) mice. Together, these findings suggest that stathmin plays an essential role in the maintenance of axonal integrity.

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