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A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population

Authors
  • Ou, Judy Y.1, 2
  • Fowler, Brynn1
  • Ding, Qian3
  • Kirchhoff, Anne C.1, 2
  • Pappas, Lisa3
  • Boucher, Kenneth3
  • Akerley, Wallace1
  • Wu, Yelena3, 4
  • Kaphingst, Kimberly1, 5
  • Harding, Garrett1
  • Kepka, Deanna1, 6
  • 1 Huntsman Cancer Institute at the University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
  • 2 University of Utah, Department of Pediatrics, 295 Chipeta Way, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
  • 3 University of Utah, Study Design and Biostatistics Center, 295 Chipeta Way, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
  • 4 University of Utah, Department of Family and Preventive Medicine, 375 Chipeta Way, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
  • 5 University of Utah, Department of Communication, 255 S Central Campus Dr., Rm 2400, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
  • 6 University of Utah, College of Nursing, 10 South 2000 East, Salt Lake City, UT, 84112, USA , Salt Lake City (United States)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 31, 2018
Volume
18
Issue
1
Identifiers
DOI: 10.1186/s12885-018-4002-9
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundLung cancer is the leading cause of cancer-related mortality in Utah despite having the nation’s lowest smoking rate. Radon exposure and differences in lung cancer incidence between nonmetropolitan and metropolitan areas may explain this phenomenon. We compared smoking-adjusted lung cancer incidence rates between nonmetropolitan and metropolitan counties by predicted indoor radon level, sex, and cancer stage. We also compared lung cancer incidence by county classification between Utah and all SEER sites.MethodsSEER*Stat provided annual age-adjusted rates per 100,000 from 1991 to 2010 for each Utah county and all other SEER sites. County classification, stage, and sex were obtained from SEER*Stat. Smoking was obtained from Environmental Public Health Tracking estimates by Ortega et al. EPA provided low (< 2 pCi/L), moderate (2–4 pCi/L), and high (> 4 pCi/L) indoor radon levels for each county. Poisson models calculated overall, cancer stage, and sex-specific rates and p-values for smoking-adjusted and unadjusted models. LOESS smoothed trend lines compared incidence rates between Utah and all SEER sites by county classification.ResultsAll metropolitan counties had moderate radon levels; 12 (63%) of the 19 nonmetropolitan counties had moderate predicted radon levels and 7 (37%) had high predicted radon levels. Lung cancer incidence rates were higher in nonmetropolitan counties than metropolitan counties (34.8 vs 29.7 per 100,000, respectively). Incidence of distant stage cancers was significantly higher in nonmetropolitan counties after controlling for smoking (16.7 vs 15.4, p = 0.02*). Incidence rates in metropolitan, moderate radon and nonmetropolitan, moderate radon counties were similar. Nonmetropolitan, high radon counties had a significantly higher incidence of lung cancer compared to nonmetropolitan, moderate radon counties after adjustment for smoking (41.7 vs 29.2, p < 0.0001*). Lung cancer incidence patterns in Utah were opposite of metropolitan/nonmetropolitan trends in other SEER sites.ConclusionLung cancer incidence and distant stage incidence rates were consistently higher in nonmetropolitan Utah counties than metropolitan counties, suggesting that limited access to preventative screenings may play a role in this disparity. Smoking-adjusted incidence rates in nonmetropolitan, high radon counties were significantly higher than moderate radon counties, suggesting that radon was also major contributor to lung cancer in these regions. National studies should account for geographic and environmental factors when examining nonmetropolitan/metropolitan differences in lung cancer.

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