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STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue

Authors
  • Kaltenecker, Doris1, 2, 3
  • Spirk, Katrin1, 2
  • Ruge, Frank1, 2
  • Grebien, Florian2, 4
  • Herling, Marco5
  • Rupprecht, Anne6
  • Kenner, Lukas7, 8, 9
  • Pohl, Elena E.6
  • Mueller, Kristina M.1, 2
  • Moriggl, Richard1, 2
  • 1 Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210, Vienna, Austria
  • 2 Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria
  • 3 Institute for Diabetes and Cancer (IDC), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
  • 4 Institute for Medical Biochemistry, University of Veterinary Medicine, 1210, Vienna, Austria
  • 5 Laboratory of Lymphocyte Signaling and Oncoproteome, Department I of Internal Medicine, CIO Aachen-Bonn-Cologne-Duesseldorf, Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
  • 6 Unit of Physiology and Biophysics, University of Veterinary Medicine, 1210, Vienna, Austria
  • 7 Unit of Pathology of Laboratory Animals, University of Veterinary Medicine, Vienna, 1210, Vienna, Austria
  • 8 Department of Pathology, Medical University Vienna, 1090, Vienna, Austria
  • 9 Christian Doppler Laboratory for Applied Metabolomics, Medical University Vienna, 1090, Vienna, Austria
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
May 28, 2020
Volume
40
Identifiers
DOI: 10.1016/j.molmet.2020.101026
PMID: 32473405
PMCID: PMC7322099
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Impaired temperature maintenance in mice deficient in adipocyte STAT5 after acute cold exposure. • Blocked β3-adrenergic induction of lipolysis and PKA activity in BAT upon STAT5 deficiency. • Reduced respiratory capacity in primary differentiated brown adipocytes lacking STAT5. • Diminished brown remodeling of STAT5 deficient ScWAT after chronic β3-adrenergic stimulation.

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