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Staphylococcal enterotoxin B-induced T-cell anergy is mediated by regulatory T cells.

Authors
  • Wang, Z Q
  • Orlikowsky, T
  • Dudhane, A
  • Trejo, V
  • Dannecker, G E
  • Pernis, B
  • Hoffmann, M K
Type
Published Article
Journal
Immunology
Publication Date
Jul 01, 1998
Volume
94
Issue
3
Pages
331–339
Identifiers
PMID: 9767414
Source
Medline
License
Unknown

Abstract

Naive T cells mount a vigorous proliferative response to superantigen (SAg) stimulation in vivo. The proliferative response is followed by a partial deletion of responder T cells. Part of the deletion process has recently been attributed to the action of regulatory cytotoxic T cells that recognize major histocompatibility complex (MHC) class I-associated antigen receptor determinants on the target cell surface. Responder T cells that survived the SAg response were found to be incapable of generating a secondary proliferative response to a SAg challenge. We show here that this 'anergy' is enforced by CD8-positive regulatory suppressive T cells. These regulatory cells inhibit cell division of preactivated T cells but not the Sag response of naive T cells. Regulatory T cells are not generated in the presence of cyclosporin A and, once activated, become inactivated or deleted when restimulated in the presence of this immunosuppressive drug.

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