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[Standardization of the index of biological activity of the multi-component antibiotic neomycin].

Authors
Type
Published Article
Journal
Antibiotiki
Publication Date
Volume
28
Issue
7
Pages
526–530
Identifiers
PMID: 6625548
Source
Medline

Abstract

The characteristic features of determination of the biological activity of neomycin and its separate components A, B and C were studied. Different sensitivity of 5 test microbes to neomycins A, B and C was observed. Bac. subtilis ATCC 6633 and Bac. cereus, var. myc. 537 were the most sensitive to neomycin A. Sar. lutea were not sensitive to neomycins A and C. The diffusion capacity of neomycin A was shown to be different from that of neomycins B and C. Even minute admixtures of neomycin A in the preparations of neomycin significantly changes the dose-response curves and affected the results of the biological activity determination.

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