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Stage III neuroblastoma over 1 year of age at diagnosis: improved survival with intensive multimodality therapy including multiple alkylating agents.

Authors
  • West, D C
  • Shamberger, R C
  • Macklis, R M
  • Kozakewich, H P
  • Wayne, A S
  • Kreissman, S G
  • Korf, B R
  • Lavally, B
  • Grier, H E
Type
Published Article
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Publication Date
Jan 01, 1993
Volume
11
Issue
1
Pages
84–90
Identifiers
PMID: 8418247
Source
Medline
License
Unknown

Abstract

Intensive multimodality treatment including MADDOC and induction MADDOC chemotherapy provides a very good EFS for children older than 1 year who have stage III neuroblastoma. Children classified as favorable according to the Shimada system have a better prognosis. Patients whose tumors demonstrate N-myc amplification have a poor prognosis despite therapy.

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