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Stability studies of C-4',6' acetal benzylmaltosides synthesized as inhibitors of smooth muscle cell proliferation.

Authors
  • Mayer, Scott C
  • Gallaway, William
  • Kulishoff, John
  • Yin, Maisheng
  • Gadamasetti, Vidya
  • Mitchell, Robert
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jun 07, 2004
Volume
14
Issue
11
Pages
2829–2833
Identifiers
PMID: 15125941
Source
Medline
License
Unknown

Abstract

In our investigations to synthesize inhibitors of smooth muscle cell (SMC) proliferation, compound 6a displayed submicromolar activity in in vitro antiproliferative assays and reduced intimal thickening using a rat balloon angioplasty model via i.v. administration. In order to identify analogs that could be administered orally, the chemical instability of the C-4',6' acetal of compound 6a was addressed. Several novel variants with increased acid stability and comparable in vitro activity were prepared.

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