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Stability of Default-Mode Network Activity in the Aging Brain

Authors
  • Beason-Held, L. L.1, 2, 3
  • Kraut, M. A.2
  • Resnick, S. M.1
  • 1 NIH, Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD, USA , Baltimore (United States)
  • 2 Johns Hopkins University School of Medicine, Dept. of Neurology, Baltimore, MD, USA , Baltimore (United States)
  • 3 NIA/LPC, 251 Bayview Blvd., Baltimore, MD, 21224-6825, USA , Baltimore (United States)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Jan 14, 2009
Volume
3
Issue
2
Pages
123–131
Identifiers
DOI: 10.1007/s11682-008-9054-z
Source
Springer Nature
Keywords
License
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Abstract

Activity attributed to the default-mode occurs during the resting state and is thought to represent self-referential and other intrinsic processes. Although activity in default-associated regions changes across the lifespan, little is known about the stability of default-mode activity in the healthy aging brain. We investigated changes in rest-specific activity across an 8 year period in older participants in the Baltimore Longitudinal Study of Aging (BLSA) neuroimaging study. Comparison of resting-state and recognition memory PET regional cerebral blood flow conditions from baseline and 8-year follow-up shows relative stability of rest-specific activity over time in medial frontal/anterior cingulate, hippocampal and posterior cingulate regions commonly associated with the default-mode. In contrast, prefrontal, parahippocampal and occipital cortical regions, which are not typically associated with default-mode activity, show changes over time. Overall, activity in the major components of the default-mode network remains stable in healthy older individuals, a finding which may assist in identifying factors that discriminate between normal and pathological aging.

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