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Stability of captopril in SyrSpend SF.

Authors
  • Geiger, Christine M
  • Sorenson, Bridget
  • Whaley, Paul A
Type
Published Article
Journal
International journal of pharmaceutical compounding
Publication Date
Jan 01, 2013
Volume
17
Issue
4
Pages
336–338
Identifiers
PMID: 24261148
Source
Medline
License
Unknown

Abstract

Captopril is an angiotensin-converting enzyme inhibitor available as a tablet. Patients who are unable to take tablets have led compounding pharmacies to seek alternative dosage forms including solutions and suspensions. The objective of this study was to determine the stability of captopril in sorbitol-free, alcohol-free SyrSpend SF suspending agent. The studied samples were compounded into a 0.8-mg/mL suspension and stored in low-actinic plastic bottles at temperatures between 2 degrees C to 8 degrees C. Six samples were assayed at each time point out to 32 days by a stability-indicating high-performance liquid chromatography method. The samples remained within 90% to 110% of the initial concentration throughout day 14 of the study. Based on the data collected, the beyond- use date of these preparations is 14 days when protected from light and refrigerated.

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