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Stability of antigen E in commercially prepared ragweed pollen extracts.

Authors
  • Center, J G
  • Shuller, N
  • Zeleznick, L D
Type
Published Article
Journal
Developments in biological standardization
Publication Date
Jan 01, 1975
Volume
29
Pages
114–122
Identifiers
PMID: 1149927
Source
Medline
License
Unknown

Abstract

Aqueous ragweed pollen extracts (20,000 PNU/ml or 78,000 PNU/ml) lose 50% of their Antigen E content within 5 months of storage at 4 degrees C. Glycerinated extracts and lyophilized ragweed pollen extracts retain their Antigen E content for over 15 months with little or no loss. The preservative phenol in aqueous extracts is destructive to Antigen E probably by protein denaturation. The stability of ragweed extracts as measured by Antigen E content is markedly enhanced with little loss after 15 month storage at 4 degrees C, when the extract is prepared as an alum precipitated suspension.

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