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Squamous cell carcinoma of the mandible - Patterns of metastasis and disease recurrence in dependence of localization and therapy.

Authors
  • Moratin, Julius1
  • Horn, Dominik2
  • Metzger, Karl3
  • Ristow, Oliver3
  • Flechtenmacher, Christa4
  • Engel, Michael3
  • Hoffmann, Jürgen3
  • Freier, Kolja2
  • Freudlsperger, Christian3
  • 1 University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. Electronic address: [email protected] , (Germany)
  • 2 Saarland University Hospital, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. K. Freier), Kirrberger Straße, D-66424 Homburg, Germany. , (Germany)
  • 3 University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery (Head of Department: Prof. Dr. Dr. J. Hoffmann), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. , (Germany)
  • 4 University of Heidelberg, Institute of Pathology (Head of Department: Prof. Dr. P. Schirmacher), Im Neuenheimer Feld 224, D-69120 Heidelberg, Germany. , (Germany)
Type
Published Article
Journal
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
Publication Date
Nov 01, 2020
Identifiers
DOI: 10.1016/j.jcms.2020.10.006
PMID: 33199211
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection. 120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies. Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients. Copyright © 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

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