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Sputum neutrophilia can mask eosinophilic bronchitis during exacerbations.

Authors
  • D'silva, Liesel1
  • Allen, Christopher J
  • Hargreave, Frederick E
  • Parameswaran, Krishnan
  • 1 Firestone Institute for Respiratory Health, St. Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
Type
Published Article
Journal
Canadian respiratory journal
Publication Date
Jan 01, 2007
Volume
14
Issue
5
Pages
281–284
Identifiers
PMID: 17703243
Source
Medline
License
Unknown

Abstract

A neutrophilic exacerbation of airway disease was observed to mask sputum eosinophilia in one-third of patients who had sputum cell counts available before and after antibiotic therapy. Hence, the absence of sputum eosinophilia during an infective exacerbation should not be used as an indication to reduce the dose of corticosteroids. To optimize therapy, repeat sputum cell count measurements are recommended after antibiotic treatment before changing corticosteroid treatment.

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