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Spotlight on CRISPR in Strongyloides Parasitic Nematodes.

Authors
  • Ward, Jordan D1
  • 1 Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. Electronic address: [email protected]
Type
Published Article
Journal
Trends in parasitology
Publication Date
Nov 23, 2017
Identifiers
DOI: 10.1016/j.pt.2017.11.005
PMID: 29174224
Source
Medline
Keywords
License
Unknown

Abstract

Parasitic nematodes are biomedically and economically important, but many are genetically intractable which limits our understanding of their molecular and cellular biology. Gang et al. report CRISPR/Cas9 genome editing in parasites of the genus Strongyloides, generating both knock-outs and knock-ins, and demonstrated heritability of the modifications, a crucial advance in the field.

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