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Spontaneous regression and complete disappearance of the vein of Galen aneurysmal malformation

Authors
  • Mahmoodi, Ramin1
  • Habibi, Zohreh2
  • Heidari, Vahid2
  • Nejat, Farideh2
  • 1 Tehran University of Medical Science, Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran, Iran , Tehran (Iran)
  • 2 Tehran University of Medical Science, Department of Neurosurgery, Children’s Hospital Medical Center, Tehran, Iran , Tehran (Iran)
Type
Published Article
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Publication Date
Feb 11, 2016
Volume
32
Issue
4
Pages
593–598
Identifiers
DOI: 10.1007/s00381-016-3033-2
Source
Springer Nature
Keywords
License
Yellow

Abstract

IntroductionThrombosis is frequently observed in Galen malformation, but propagation of thrombosis resulting in the disappearance of the aneurysmal malformation is a very rare clinical condition.Case reportA rare case of spontaneous regression and disappearance of the vein of Galen aneurysmal malformation (VoGAM) in a pediatric patient with repeated generalized seizure, increased head circumference, and congestive heart failure is recorded. The course of regression from infancy to 8 years of age has been depicted. Radiological studies initially demonstrated VoGAM complicated by an intra-cerebral hemorrhage and hydrocephalus, which later underwent spontaneous regression. Long-term clinical and radiological follow-up is presented.DiscussionDifferent conditions including hemodynamic alteration, compression of adjacent hematoma, and narrowing of related vascular structures have been described to cause thrombosis of VoGAM. The relevant literature to address possible mechanism is reviewed.

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