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Spontaneous poorly differentiated carcinoma with cells positive for vimentin in a salivary gland of a young rat.

Authors
  • Nishikawa, Satomi
  • Sano, Fumiko
  • Takagi, Kan
  • Okada, Miyoko
  • Sugimoto, Jiro
  • Takagi, Shiro
Type
Published Article
Journal
Toxicologic Pathology
Publisher
SAGE Publications
Publication Date
Feb 01, 2010
Volume
38
Issue
2
Pages
315–318
Identifiers
DOI: 10.1177/0192623309358905
PMID: 20124499
Source
Medline
License
Unknown

Abstract

Spontaneous salivary gland tumors in rats are rare. The authors report a poorly differentiated carcinoma of a submandibular gland in a ten-week-old rat that was positive for vimentin. Microscopically, the neoplastic cells showed a diffuse growth pattern in most areas of the tumor mass and a nestlike structure in a part of the peripheral area. Immunohistochemically, the cells were positive for keratin and vimentin but not for alpha-smooth muscle actin. Ultrastructurally, desmosome-like structures were observed. Based on these findings, the tumor was diagnosed as a poorly differentiated carcinoma. The origin of the neoplastic cells would be either acinar or ductal cells. This suggests that acinar or ductal cells have the potential to transform into vimentin-expressing cells.

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