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Spontaneous morphine withdrawal from the rat spinal cord.

Authors
  • Marshall, D C
  • Buccafusco, J J
Type
Published Article
Journal
Experientia
Publication Date
Sep 15, 1985
Volume
41
Issue
9
Pages
1151–1152
Identifiers
PMID: 4043325
Source
Medline
License
Unknown

Abstract

A characteristic and reproducible sign of narcotic withdrawal is the naloxone induced increase in arterial pressure. In morphine-dependent rats allowed to undergo spontaneous withdrawal (6-24 h) and then transected at the spinal C-1 level, arterial pressure was maintained at a significantly higher level than either spinal-transected nondependent controls or morphine-dependent, spinal-transected rats pithed from C-1 to L-4. These findings indicate that the morphine-dependent spinal cord, independent of supraspinal influences, is able to exhibit an autonomic component of spontaneous withdrawal.

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