Affordable Access

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.

Authors
  • Fox, Michael D
  • Raichle, Marcus E
Type
Published Article
Journal
Nature reviews. Neuroscience
Publication Date
Sep 01, 2007
Volume
8
Issue
9
Pages
700–711
Identifiers
PMID: 17704812
Source
Medline
License
Unknown

Abstract

The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

Report this publication

Statistics

Seen <100 times