Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.
- Authors
- Type
- Published Article
- Journal
- Journal of Natural Products
- Publisher
- American Chemical Society
- Publication Date
- Mar 27, 2015
- Volume
- 78
- Issue
- 3
- Pages
- 493–499
- Identifiers
- DOI: 10.1021/np5009762
- PMID: 25668560
- Source
- Medline
- License
- Unknown
Abstract
Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.