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Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.

Authors
  • Bertin, Matthew J
  • Schwartz, Sarah L
  • Lee, John
  • Korobeynikov, Anton
  • Dorrestein, Pieter C
  • Gerwick, Lena
  • Gerwick, William H
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Mar 27, 2015
Volume
78
Issue
3
Pages
493–499
Identifiers
DOI: 10.1021/np5009762
PMID: 25668560
Source
Medline
License
Unknown

Abstract

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

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