Affordable Access

deepdyve-link
Publisher Website

Splicing factor TRA2B is required for neural progenitor survival.

Authors
  • Roberts, Jacqueline M1
  • Ennajdaoui, Hanane
  • Edmondson, Carina
  • Wirth, Brunhilde
  • Sanford, Jeremy R
  • Chen, Bin
  • 1 Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California, 95064.
Type
Published Article
Journal
The Journal of Comparative Neurology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 01, 2014
Volume
522
Issue
2
Pages
372–392
Identifiers
DOI: 10.1002/cne.23405
PMID: 23818142
Source
Medline
Keywords
License
Unknown

Abstract

Alternative splicing of pre-mRNAs can rapidly regulate the expression of large groups of proteins. The RNA binding protein TRA2B (SFRS10) plays well-established roles in developmentally regulated alternative splicing during Drosophila sexual differentiation. TRA2B is also essential for mammalian embryogenesis and is implicated in numerous human diseases. Precise regulation of alternative splicing is critical to the development and function of the central nervous system; however, the requirements for specific splicing factors in neurogenesis are poorly understood. This study focuses on the role of TRA2B in mammalian brain development. We show that, during murine cortical neurogenesis, TRA2B is expressed in both neural progenitors and cortical projection neurons. Using cortex-specific Tra2b mutant mice, we show that TRA2B depletion results in apoptosis of the neural progenitor cells as well as disorganization of the cortical plate. Thus, TRA2B is essential for proper development of the cerebral cortex.

Report this publication

Statistics

Seen <100 times