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Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria

Authors
  • Avery, Vicky M.
  • Buffet, Pierre A.
  • Duez, Julien
  • Holleran, John P.
  • Ndour, Papa Alioune
  • Loganathan, Sasdekumar
  • Amireault, Pascal
  • Français, Olivier
  • El Nemer, Wassim
  • Le Pioufle, Bruno
  • Amado, Inês F.
  • Garcia, Sylvie
  • Catherine Lavazec
  • Caroline Le Van Kim
  • Lavazec, Catherine
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Jul 13, 2015
Volume
59
Issue
7
Pages
4206–4214
Identifiers
DOI: 10.1128/aac.05030-14
PMID: 25941228
PMCID: PMC4468678
OAI: oai:HAL:hal-01158996v1
Source
USPC - SET - SVS
Keywords
License
Green
External links

Abstract

Background: Plasmodium falciparum is transmitted from humans to Anopheles mosquito vectors via the sexual erythrocytic forms termed gametocytes. Erythrocyte filtration through microsphere layers (microsphiltration) had shown that circulating gametocytes were deformable. Compounds reducing gametocyte deformability would induce their splenic clearance, thus remove them from the blood circulation and block malaria transmission.

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