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Hyperpolarized 15N-labeled, deuterated tris(2-pyridylmethyl)amine as an MRI sensor of freely available Zn2+

Authors
  • Suh, Eul Hyun1
  • Park, Jae Mo1, 2, 3
  • Lumata, Lloyd4
  • Sherry, A. Dean1, 2, 4
  • Kovacs, Zoltan1, 4
  • 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA , Dallas (United States)
  • 2 Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA , Dallas (United States)
  • 3 University of Texas at Dallas, Richardson, TX, 75080, USA , Richardson (United States)
  • 4 University of Texas Dallas, Richardson, TX, 75080, USA , Richardson (United States)
Type
Published Article
Journal
Communications Chemistry
Publisher
Nature Publishing Group UK
Publication Date
Dec 09, 2020
Volume
3
Issue
1
Identifiers
DOI: 10.1038/s42004-020-00426-6
Source
Springer Nature
License
Green

Abstract

Dynamic nuclear polarization coupled with 15N magnetic resonance imaging can afford quantitative imaging of biologically important metal ions. Here the authors prepare 15N-enriched, d6-deuterated tris(2-pyridylmethyl)amine as an MRI sensor for freely available Zn2+.

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