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Bioluminescence-Driven Optogenetics.

Authors
  • Sureda-Vives, Macià1, 2
  • Sarkisyan, Karen S1, 2, 3
  • 1 Synthetic Biology Group, MRC London Institute of Medical Sciences, London W12 0NN, UK.
  • 2 Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
  • 3 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.
Type
Published Article
Journal
Life (Basel, Switzerland)
Publication Date
Nov 28, 2020
Volume
10
Issue
12
Identifiers
DOI: 10.3390/life10120318
PMID: 33260589
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels. However, the potential of bioluminescence beyond reporter technologies remains largely unexplored. Here, we provide an overview of the emerging approaches employing bioluminescence as a biological light source that triggers physiological events and controls cell behaviour and discuss its possible future application in synthetic biology.

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