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Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation.

Authors
  • Nam, Joo Hyun1, 2
  • Jung, Hyo Won3
  • Chin, Young-Won4
  • Yang, Won-Mo5
  • Bae, Hyo Sang6
  • Kim, Woo Kyung2, 7
  • 1 a Department of Physiology , Dongguk University College of Medicine , Gyeongju , Republic of Korea. , (North Korea)
  • 2 b Channelopathy Research Center (CRC) , Dongguk University College of Medicine , Goyang , Gyeonggi-do , Republic of Korea. , (North Korea)
  • 3 c College of Korean Medicine , Dongguk University , Gyeongju , Republic of Korea. , (North Korea)
  • 4 d College of Pharmacy , Dongguk University , Goyang , Gyeonggi-do , Republic of Korea. , (North Korea)
  • 5 e Department of Biochemistry , Dongguk University College of Medicine , Gyeongju , Republic of Korea. , (North Korea)
  • 6 f Department of Sasang Constitutional Medicine , College of Korean Medicine, Dongguk University , Goyang , Gyeonggi-do , Republic of Korea. , (North Korea)
  • 7 g Department of Internal Medicine, Graduate School of Medicine , Dongguk University , Goyang , Gyeonggi-do , Republic of Korea. , (North Korea)
Type
Published Article
Journal
Pharmaceutical Biology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Dec 01, 2017
Volume
55
Issue
1
Pages
1324–1329
Identifiers
DOI: 10.1080/13880209.2017.1300819
PMID: 28290212
Source
Medline
Keywords
License
Unknown

Abstract

Our results suggested that SH extract could treat abnormal skin barrier pathologies in AD through modulation of the activities of the calcium ion channels Orai1 and TRPV3 and inhibition of mast cell degranulation. This is the first report of an herbal effect on the modulation of ion channels associated with skin barrier disruption in AD pathogenesis.

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