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Spices to Control COVID-19 Symptoms: Yes, but Not Only…

Authors
  • Bousquet, Jean
  • Czarlewski, Wienczyslawa
  • Zuberbier, Torsten
  • Mullol, Joaquim
  • Blain, Hubert
  • Cristol, Jean-Paul
  • De La Torre, Rafael
  • Le Moing, Vincent
  • Pizarro Lozano, Nieves
  • Bedbrook, Anna
  • Agache, Ioana
  • Akdis, Cezmi A.
  • Canonica, G. Walter
  • Cruz, Alvaro A.
  • Fiocchi, Alessandro
  • Fonseca, Joao A.
  • Fonseca, Susana
  • Gemicioğlu, Bilun
  • Haahtela, Tari
  • Iaccarino, Guido
  • And 19 more
Type
Published Article
Journal
International Archives of Allergy and Immunology
Publisher
S. Karger AG
Publication Date
Dec 22, 2020
Pages
1–7
Identifiers
DOI: 10.1159/000513538
PMID: 33352565
PMCID: PMC7900475
Source
PubMed Central
Keywords
License
Unknown

Abstract

There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.

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