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The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

Authors
  • Jin, Lei1
  • Liu, Wei-Ren1
  • Tian, Meng-Xin1
  • Fan, Jia1, 2
  • Shi, Ying-Hong1
  • 1 Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Department of Liver Surgery, Liver Cancer Institute, 180 FengLin Road, Shanghai, 200032, China , Shanghai (China)
  • 2 Fudan University, Institutes of Biomedical Sciences, Shanghai, People’s Republic of China , Shanghai (China)
Type
Published Article
Journal
World Journal of Surgical Oncology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 29, 2016
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s12957-016-0884-7
Source
Springer Nature
Keywords
License
Green

Abstract

Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.

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