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Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm.

Authors
  • Tosaka, M
  • Okajima, F
  • Hashiba, Y
  • Saito, N
  • Nagano, T
  • Watanabe, T
  • Kimura, T
  • Sasaki, T
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Dec 01, 2001
Volume
32
Issue
12
Pages
2913–2919
Identifiers
PMID: 11739995
Source
Medline
License
Unknown

Abstract

S1P induces vasocontraction in the canine basilar artery in vitro and in vivo, possibly through a mechanism involving activation of the Rho/Rho-kinase pathway. Thus, S1P might be considered as a novel spasmogenic substance involved in cerebral vasospasm after subarachnoid hemorrhage.

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