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Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp.

Authors
  • Whitson, Emily L.
  • Bugni, Tim S.
  • Chockalingam, Priya S.
  • Concepcion, Gisela P.
  • Harper, Mary Kay
  • He, Min
  • Hooper, John N. A.
  • Mangalindan, Gina C.
  • Ritacco, Frank
  • Ireland, Chris M.
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Jun 18, 2008
Volume
71
Issue
7
Pages
1213–1217
Identifiers
DOI: 10.1021/np8001628
PMID: 18558742
PMCID: PMC2593898
Source
PubMed Central
License
Green

Abstract

Three new sterol sulfates, spheciosterol sulfates A−C ( 1 − 3 ), and the known sterol sulfate topsentiasterol sulfate E ( 4 ) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 − 4 inhibited PKCζ with IC50 values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1 − 4 also inhibited NF-κB activation with EC50 values of 12−64 μM.

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