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The SPFH domain-containing proteins: more than lipid raft markers.

Authors
  • Browman, Duncan T
  • Hoegg, Maja B
  • Robbins, Stephen M
Type
Published Article
Journal
Trends in Cell Biology
Publisher
Elsevier
Publication Date
Aug 01, 2007
Volume
17
Issue
8
Pages
394–402
Identifiers
PMID: 17766116
Source
Medline
License
Unknown

Abstract

Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a potential mechanism for compartmentalizing cellular functions within the plane of biological membranes. SPFH domain-containing proteins are found in lipid raft microdomains in diverse cellular membranes. The functions of these proteins are just beginning to be elucidated. Recent advances in the understanding of structural features and their roles within lipid rafts include a potential function for SPFH proteins in the formation of membrane microdomains and lipid raft-associated processes, such as endocytosis and mechanosensation.

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