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Sperm DNA integrity in men treated for childhood cancer.

Authors
  • Romerius, Patrik
  • Ståhl, Olof
  • Moëll, Christian
  • Relander, Thomas
  • Cavallin-Ståhl, Eva
  • Gustafsson, Helen
  • Löfvander Thapper, Kerstin
  • Jepson, Katarina
  • Spanò, Marcello
  • Wiebe, Thomas
  • Lundberg Giwercman, Yvonne
  • Giwercman, Aleksander
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Aug 01, 2010
Volume
16
Issue
15
Pages
3843–3850
Identifiers
DOI: 10.1158/1078-0432.CCR-10-0140
PMID: 20519359
Source
Medline
License
Unknown

Abstract

DFI was increased in CCS, with those treated with chemotherapy being the only exception. This sperm DNA impairment may be associated with the disease per se rather than due to the treatment, and may have negative consequences in terms of fertility and risk of transmission to the offspring.

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