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The spectrum of 5-fluorouracil cardiotoxicity.

Authors
  • Dalzell, Jonathan R
  • Samuel, Leslie M
Type
Published Article
Journal
Anti-Cancer Drugs
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 2009
Volume
20
Issue
1
Pages
79–80
Identifiers
PMID: 19353811
Source
Medline
License
Unknown

Abstract

Cardiotoxicity is a rare but serious complication of 5-fluorouracil therapy. Coronary vasospasm and, less frequently, acute myocarditis have been identified as underlying mechanisms. We report a case of severe toxicity in a relatively young and fit male patient being treated for metastatic colonic adenocarcinoma displaying characteristics that cannot be explained by either mechanism alone.

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