Affordable Access

Spectrophotometric determination of penicillamine and carbocisteine based on formation of metal complexes.

Authors
Type
Published Article
Journal
Il Farmaco
0014-827X
Publisher
Elsevier
Publication Date
Volume
59
Issue
6
Pages
493–503
Identifiers
PMID: 15178313
Source
Medline

Abstract

A simple spectrophotometric method was developed for the determination of penicillamine and carbocisteine. The method depends on complexation of penicillamine with Ni, Co and Pb ions in acetate buffer pH of 6.3, 6.5 and 5.3, respectively, and carbocisteine with Cu and Ni ions in borate buffer pH of 6.7; 1-70 microg/ml of these drugs could be determined by measuring the absorbance of each complex at its specific lambdamax. The results obtained are in good agreement with those obtained using the official methods. The proposed method was successfully applied for the determination of these compounds in their dosage forms. Also, the molar ratio and stability constant of the metal complexes were calculated and a proposal of the reaction pathway was postulated.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments