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Spectrophotometric determination of certain antidepressants in pharmaceutical preparations.

Authors
  • Onal, Armağan1
  • Kepekci, S Evrim
  • Cetin, S Müge
  • Ertürk, Sidika
  • 1 Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, 34116, Beyazit, Istanbul, Turkey. [email protected] , (Turkey)
Type
Published Article
Journal
Journal of AOAC International
Publication Date
Jan 01, 2006
Volume
89
Issue
4
Pages
966–971
Identifiers
PMID: 16915831
Source
Medline
License
Unknown

Abstract

Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or bromophenol blue) to produce yellow-colored ion-pair complexes in acidic buffers. After extracting in chloroform, the ion-pair complexes are spectrophotometrically determined at the optimum wavelength. Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 microg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods.

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