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Spectrofluorometric studies on the binding of the antitumor drugs ametantrone and mitoxantrone to bovine serum albumin.

Authors
  • al-Gailany, K A
Type
Published Article
Journal
Biomedica biochimica acta
Publication Date
Jan 01, 1990
Volume
49
Issue
10
Pages
1091–1096
Identifiers
PMID: 2127883
Source
Medline
License
Unknown

Abstract

Mitoxantrone binds tightly to one high affinity site, while ametantrone was found to bind to at least two different sites. The two compounds were able to displace the fluorescent probe 7,12-dimethylbenzanthracene from its hydrophobic site on the bovine serum albumin molecule, but at high ametantrone concentration, no further displacement was noticed, which may indicate that at concentrations higher than 50 microM conformational changes in the protein molecule may be caused by ametantrone.

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