Mitoxantrone binds tightly to one high affinity site, while ametantrone was found to bind to at least two different sites. The two compounds were able to displace the fluorescent probe 7,12-dimethylbenzanthracene from its hydrophobic site on the bovine serum albumin molecule, but at high ametantrone concentration, no further displacement was noticed, which may indicate that at concentrations higher than 50 microM conformational changes in the protein molecule may be caused by ametantrone.
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This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2127883