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Spectral, thermal and biological characterization of complexes with a Schiff base bearing triazole moiety as potential antimicrobial species

  • Calu, Larisa1, 2
  • Badea, Mihaela1
  • Čelan Korošin, Nataša3
  • Chifiriuc, Mariana Carmen4, 5
  • Bleotu, Coralia6
  • Stanică, Nicolae7
  • Silvestro, Luigi8
  • Maurer, Martin8
  • Olar, Rodica2
  • 1 University of Bucharest, Department of Inorganic Chemistry, Faculty of Chemistry, 90-92 Panduri Str., Bucharest, 050663, Romania , Bucharest (Romania)
  • 2 National Institute R&D for Biological Sciences, Cellular Dynamics and Flow Cytometry Department, 296 Splaiul Independenței, Bucharest, 060031, Romania , Bucharest (Romania)
  • 3 University of Ljubljana, Department of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, Večna pot 113, Ljubljana, 1000, Slovenia , Ljubljana (Slovenia)
  • 4 University of Bucharest, Department of Microbiology, Faculty of Biology, 1-3 Aleea Portocalilor St., Bucharest, 60101, Romania , Bucharest (Romania)
  • 5 Research Institute of the University of Bucharest, ICUB, Splaiul Independenței 91-95, Bucharest, Romania , Bucharest (Romania)
  • 6 Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania , Bucharest (Romania)
  • 7 Romanian Academy, “Ilie Murgulescu” Physical Chemistry Institute, 202 Splaiul Independenței, Bucharest, 77208, Romania , Bucharest (Romania)
  • 8 3S-Pharmacological Consultation & Research GmbH, 1 Koenigsbergerstrasse, Harpstedt, 27243, Germany , Harpstedt (Germany)
Published Article
Journal of Thermal Analysis and Calorimetry
Springer Netherlands
Publication Date
Oct 31, 2018
DOI: 10.1007/s10973-018-7871-x
Springer Nature


A novel series of complexes ML(ClO4)·nH2O (M: Co, Ni, Cu, Zn; HL: 2-[(E)-(1H-1,2,4-triazol-3-ylimino)methyl]phenol) have been synthesized and characterized as mononuclear species. The features of complexes have been assigned from microanalytical, FAB-MS, IR, UV–Vis-NIR, EPR and magnetic data. The IR spectra indicate the chelate behaviour of Schiff base and the perchlorate presence either as free ion or as ligand. Electronic and magnetic data are consistent with hexa-coordination of Co(II) and Ni(II) and penta-coordination for Cu(II) ions in complexes. The simultaneous TG-DSC/MS measurements evidenced processes as water (hydration or coordination) elimination, perchlorate decomposition as well as Schiff base both fragmentation and oxidative degradation. The in vitro screening of the antimicrobial behaviour on Gram-positive and Gram-negative bacteria, as well as on fungal strains, indicates a good activity for Cu(II) and Zn(II) complexes against both planktonic or adherent cells. Moreover, Cu(II) complex also exhibited a promising antiproliferative activity on HT 29 cell line.

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