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Specificity of the proteus antibody response in rheumatoid arthritis.

Authors
  • Deighton, C M
  • Gray, J
  • Bint, A J
  • Walker, D J
Type
Published Article
Journal
Annals of the rheumatic diseases
Publication Date
Nov 01, 1992
Volume
51
Issue
11
Pages
1206–1207
Identifiers
PMID: 1466597
Source
Medline
License
Unknown

Abstract

Antibodies to proteus were determined by indirect immunofluorescence in 146 serum samples from patients with rheumatoid arthritis (RA). An autoantibody screen was performed in the same samples and in 52 of these antibody titres to the viruses influenza A, adenovirus, rubella, and parvovirus were determined. There was no significant correlation between proteus antibodies and any of the other antibodies tested. Dividing the samples into those from patients with active (C reactive protein > 10 mg/l) and inactive RA showed that the only antibodies to be significantly increased in active RA were the proteus antibodies. These observations suggest that the proteus antibody response in RA is specific.

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