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The Specificity of the Persistent IgM Neutralizing Antibody Response in Zika Virus Infections among Individuals with Prior Dengue Virus Exposure.

Authors
  • Calvert, Amanda E1
  • Horiuchi, Kalanthe2
  • Boroughs, Karen L1
  • Ong, Yee T1
  • Anderson, Kimberly M1
  • Biggerstaff, Brad J2
  • Stone, Mars3, 4
  • Simmons, Graham3, 4
  • Busch, Michael P3, 4
  • Huang, Claire Y-H1
  • 1 Arbovirus Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
  • 2 Office of the Director, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
  • 3 Vitalant Research Institute, San Francisco, California, USA.
  • 4 Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
Type
Published Article
Journal
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Publication Date
Jul 19, 2021
Volume
59
Issue
8
Identifiers
DOI: 10.1128/JCM.00400-21
PMID: 33980647
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Dengue viruses (DENV) and Zika virus (ZIKV) are related mosquito-borne flaviviruses with similar disease manifestations, vector ecologies, and geographic ranges. The ability to differentiate these viruses serologically is vital due to the teratogenic nature of ZIKV and the potential confounding of preexisting cross-reactive anti-DENV antibodies. Here, we illustrate the kinetics of the IgM neutralizing antibody (NAb) response using longitudinal samples ranging from acute ZIKV infection to late convalescence from individuals with evidence of prior DENV infection. By serially depleting antibody isotypes prior to the neutralization assay, we determined that IgM contributes predominantly to ZIKV neutralization and is less cross-reactive than the IgG NAb. The IgM NAb peaked around 14 days (95% confidence interval [95% CI], 13 to 15) and had a median duration of 257 days (95% CI, 133 to 427). These results demonstrate the persistence of IgM NAb after ZIKV infection and imply its potential role in diagnosis, vaccine evaluation, serosurveillance, and research on flavivirus-host interactions.

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