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Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence.

Authors
  • Wasylyk, B
  • Derbyshire, R
  • Guy, A
  • Molko, D
  • Roget, A
  • Téoule, R
  • Chambon, P
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Dec 01, 1980
Volume
77
Issue
12
Pages
7024–7028
Identifiers
PMID: 6938951
Source
Medline
License
Unknown

Abstract

A single-point mutation, consisting of a T-to-G transversion, was made in the third nucleotide of the conalbumin gene T-A-T-A-A-A-A homology sequence (the T-A-T-A or Goldberg-Hogness box). In an in vitro system, specific transcription of the mutant DNA was drastically decreased compared to the normal gene. This down-mutation is consistent with the idea that the T-A-T-A box is an important element for specific initiation of transcription.

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