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Specific increase of human entorhinal population synaptic and neuronal activity during retrieval.

Authors
  • Knake, Susanne
  • Wang, Chun Mao
  • Ulbert, Istvan
  • Schomer, Donald L
  • Halgren, Eric
Type
Published Article
Journal
NeuroImage
Publication Date
Aug 15, 2007
Volume
37
Issue
2
Pages
618–622
Identifiers
PMID: 17566769
Source
Medline
License
Unknown

Abstract

Population transmembrane currents and neuronal firing in different layers of the human entorhinal cortex (ER) were recorded during semantic and episodic memory processes using a linear array of 24 laminar microelectrodes. Both measures, as well as local broadband spectral power, increased during retrieval of newly-learned characteristics, especially in superficial layers. No differences were observed in the activity evoked by remembering people as compared to places. Semantic retrieval evoked similar activity. In contrast, intentional encoding of declarative memory evoked relatively little activity. A double-dissociation of these responses with simultaneously recorded lateral inferotemporal recordings suggests that entorhinal cortex may be specifically engaged during retrieval, across multiple memory types and materials.

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