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Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus of the rat.

Authors
  • Santos, Paula1
  • da Silva, Lilian Eslaine Costa Mendes2
  • Leão, Ricardo Maurício3
  • 1 Universidade de São Paulo (USP), Faculdade de Medicina Ribeirão Preto (FMRP), Departamento de Oftalmologia e Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Ribeirão Preto, SP, Brazil; Universidade de São Paulo (USP), Faculdade de Medicina Ribeirão Preto (FMRP), Departamento de Fisiologia, Ribeirão Preto, SP, Brazil. , (Brazil)
  • 2 Universidade de São Paulo (USP), Faculdade de Medicina Ribeirão Preto (FMRP), Departamento de Oftalmologia e Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Ribeirão Preto, SP, Brazil. , (Brazil)
  • 3 Universidade de São Paulo (USP), Faculdade de Medicina Ribeirão Preto (FMRP), Departamento de Fisiologia, Ribeirão Preto, SP, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Brazilian journal of otorhinolaryngology
Publication Date
Jan 01, 2017
Volume
83
Issue
2
Pages
155–161
Identifiers
DOI: 10.1016/j.bjorl.2016.02.011
PMID: 27174774
Source
Medline
Keywords
License
Unknown

Abstract

Our data show that a high dose of salicylate activates neurons in the DCN, pVCN and IC. The expression of these genes by high doses of salicylate strongly suggests that plastic changes in these areas are involved in the genesis of tinnitus.

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