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Specific antibody protection of the extracellular cartilage matrix against collagen antibody-induced damage.

Authors
  • Croxford, Allyson M
  • Crombie, Duncan
  • McNaughton, Donald
  • Holmdahl, Rikard
  • Nandakumar, Kutty Selva
  • Rowley, Merrill J
Type
Published Article
Journal
Arthritis & Rheumatism
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2010
Volume
62
Issue
11
Pages
3374–3384
Identifiers
DOI: 10.1002/art.27671
PMID: 20662051
Source
Medline
License
Unknown

Abstract

CII-reactive antibodies can cause cartilage damage or can be protective in vivo and in vitro, depending on their epitope specificity. Since CII antibodies of similar specificity also occur in rheumatoid arthritis in humans, more detailed studies should unravel the regulatory mechanisms operating at the effector level of arthritis pathogenesis.

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