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Species and tissue differences of histamine storage and release.

Authors
Type
Published Article
Journal
Agents and Actions
0065-4299
Publisher
Springer-Verlag
Publication Date
Volume
12
Issue
1-2
Pages
81–85
Identifiers
PMID: 6177220
Source
Medline
License
Unknown

Abstract

Histamine release by compound 48/80 was studied in vivo and in vitro in different tissues of the cat and rat. A good correlation was fond between both kinds of experiment. The histamine stores in the cat salivary gland are poorly sensitive to this histamine-liberating substance. In vitro studies with heart and lungs of the rat and guinea pig showed no correlation between the spontaneous histamine release and the release induced by compound 48/80. This finding suggests the existence of two pools of tissue histamine, both with different storage and release properties, and most probably with different functions in the body.

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