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Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers.

Authors
  • Bingham, B
  • Jones, P G
  • Uveges, A J
  • Kotnis, S
  • Lu, P
  • Smith, V A
  • Sun, S-C
  • Resnick, L
  • Chlenov, M
  • He, Y
  • Strassle, B W
  • Cummons, T A
  • Piesla, M J
  • Harrison, J E
  • Whiteside, G T
  • Kennedy, J D
Type
Published Article
Journal
British journal of pharmacology
Publication Date
Aug 01, 2007
Volume
151
Issue
7
Pages
1061–1070
Identifiers
PMID: 17549048
Source
Medline
License
Unknown

Abstract

These findings constitute the first in vitro functional assessment of R,S-AM1241 at rodent CB(2) receptors and the first characterization of the AM1241 enantiomers in recombinant cell systems and in vivo. The greater antinociceptive efficacy of S-AM1241, the functional CB(2) agonist enantiomer of AM1241, is consistent with previous observations that CB(2) agonists are effective in relief of pain.

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