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Species-specific anticoagulant and mitogenic activities of murine protein S.

Authors
  • Fernández, José A
  • Heeb, Mary J
  • Xu, Xiao
  • Singh, Itender
  • Zlokovic, Berislav V
  • Griffin, John H
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Dec 01, 2009
Volume
94
Issue
12
Pages
1721–1731
Identifiers
DOI: 10.3324/haematol.2009.009233
PMID: 19815836
Source
Medline
License
Unknown

Abstract

The spectrum of bioactivities of recombinant murine protein S with mouse plasma and smooth muscle cells is similar to that of human protein S. However, in vitro and in vivo studies of the protein C pathway in murine disease models are more appropriately performed using murine protein S. This study extends previous observations regarding the remarkable species specificity of protein S to the mouse.

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