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Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

Authors
  • Wan, Gang1
  • Fields, Brandon D.1, 2
  • Spracklin, George1, 2
  • Shukla, Aditi1
  • Phillips, Carolyn M.3
  • Kennedy, Scott1
  • 1 Harvard Medical School, Department of Genetics, Boston, MA, USA , Boston (United States)
  • 2 University of Wisconsin-Madison, Laboratory of Genetics, Madison, WI, USA , Madison (United States)
  • 3 University of Southern California, Department of Biological Sciences, Los Angeles, CA, USA , Los Angeles (United States)
Type
Published Article
Journal
Nature
Publisher
Springer Nature
Publication Date
May 16, 2018
Volume
557
Issue
7707
Pages
679–683
Identifiers
DOI: 10.1038/s41586-018-0132-0
Source
Springer Nature
License
Yellow

Abstract

ZNFX-1 and WAGO-4 localize to germ granules in early Caenorhabditis elegans embryogenesis and later separate to form independent liquid-like droplets, and the temporal and spatial ordering of these droplets may help cells to organize complex RNA processing pathways.

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