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Spastic ataxia associated with human T-cell lymphotropic virus type II infection.

Authors
  • Harrington, W J Jr
  • Sheremata, W
  • Hjelle, B
  • Dube, D K
  • Bradshaw, P
  • Foung, S K
  • Snodgrass, S
  • Toedter, G
  • Cabral, L
  • Poiesz, B
Type
Published Article
Journal
Annals of neurology
Publication Date
Apr 01, 1993
Volume
33
Issue
4
Pages
411–414
Identifiers
PMID: 8489213
Source
Medline
License
Unknown

Abstract

Human T-cell lymphotropic virus type one (HTLV-1) is associated with tropical spastic paraparesis or HTLV-I--associated myelopathy. We report 2 women with a spastic ataxic illness similar to HTLV-I--associated myelopathy infected solely with HTLV-II. Identification of HTLV-II infection was made serologically, by polymerase chain reaction, and by viral culture (in 1 woman). One woman, treated with 200 mg of danazol orally, three times daily, had pronounced improvement in ambulation, nocturnal spasticity, and nighttime urinary frequency. It appears that infection with HTLV-II may cause an illness similar to HTLV-I--associated myelopathy, but distinguished by the presence of ataxia.

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