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Soybean meal peptide Gly-Thr-Tyr-Trp could protect mice from acute alcoholic liver damage: A study of protein-protein interaction and proteomic analysis.

Authors
  • Lyu, Siwen1
  • Cai, Zhuanzhang1
  • Yang, Qi1
  • Liu, Jingbo1
  • Yu, Yiding1
  • Pan, Fengguang2
  • Zhang, Ting3
  • 1 Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. , (China)
  • 2 Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. Electronic address: [email protected]. , (China)
  • 3 Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. Electronic address: [email protected]. , (China)
Type
Published Article
Journal
Food chemistry
Publication Date
Apr 15, 2024
Volume
451
Pages
139337–139337
Identifiers
DOI: 10.1016/j.foodchem.2024.139337
PMID: 38663243
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Alcoholic liver disease (ALD) is a serious health threat. Soybean meal peptide (SMP) supplementation may protect against this damage; however, the potential mechanism underlying the specific sequence of SMPs is unclear. Protein-protein interaction and proteomic analyses are effective methods for studying functional ingredients in diseases. This study aimed to investigate the potential mechanism of action of the peptide Gly-Thr-Tyr-Trp (GTYW) on ALD using protein-protein interaction and proteomic analyses. These results demonstrate that GTYW influenced the targets of glutathione metabolism (glutathione-disulfide reductase, glutathione S-transferase pi 1, and glutathione S-transferase mu 2). It also regulated the expression of targets related to energy metabolism and amino acid conversion (trypsin-2, cysteine dioxygenase type-1, and F6SJM7). Amino acid and lipid metabolisms were identified based on Gene Ontology annotation. These results indicate that GTYW might affect alcohol-related liver disease signaling pathways. This study provides evidence of the protective and nutritional benefits of SMPs in ALD treatment. Copyright © 2023. Published by Elsevier Ltd.

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