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SOX17: escape route from immune destruction in early CRC.

Authors
  • Papavassiliou, Kostas A1
  • Adamopoulos, Christos2
  • Papavassiliou, Athanasios G3
  • 1 First University Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. , (Greece)
  • 2 Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. , (Greece)
  • 3 Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: [email protected]. , (Greece)
Type
Published Article
Journal
Trends in molecular medicine
Publication Date
Jul 01, 2024
Volume
30
Issue
7
Pages
609–611
Identifiers
DOI: 10.1016/j.molmed.2024.04.001
PMID: 38594095
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5- (LGR5-) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape. Copyright © 2024 Elsevier Ltd. All rights reserved.

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