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The source of matrix-degrading enzymes in human cancer: Problems of research reproducibility and possible solutions.

Authors
  • Madsen, Daniel H
  • Bugge, Thomas H
Type
Published Article
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press
Publication Date
Apr 27, 2015
Volume
209
Issue
2
Pages
195–198
Identifiers
DOI: 10.1083/jcb.201501034
PMID: 25918222
Source
Medline
License
Unknown

Abstract

Matrix degradation is central to tumor pathogenesis. Enzymes that degrade extracellular matrix are abundant in tumors. But which out of the complex mixture of cells that form a tumor produces them? Surprisingly, several hundred studies devoted to this question have provided confusion rather than clarity. Our analysis of these studies identifies likely reasons as to why this may be the case, which has implications for the broader issue of research reproducibility.

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