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Sorting by race/ethnicity across HIV genetic transmission networks in three major metropolitan areas in the United States.

Authors
  • Ragonnet-Cronin, Manon1, 2
  • Benbow, Nanette3
  • Hayford, Christina4
  • Poortinga, Kathleen5
  • Ma, Fangchao6
  • Forgione, Lisa A7
  • Sheng, Zhijuan8
  • Hu, Yunyin9
  • Torian, Lucia10
  • Wertheim, Joel O11
  • 1 Imperial College London, 4615, MRC Centre for Global Infectious Disease Analysis, St Mary's Campus, Paddington, London, United Kingdom of Great Britain and Northern Ireland, W2 1NY. , (United Kingdom)
  • 2 Imperial College London; [email protected]
  • 3 Northwestern University, 3270, Evanston, Illinois, United States; [email protected] , (United States)
  • 4 Northwestern University, 3270, Evanston, Illinois, United States; [email protected] , (United States)
  • 5 Los Angeles County Department of Public Health, 5147, Los Angeles, California, United States; [email protected] , (United States)
  • 6 Illinois Department of Public Health, 7455, Springfield, Illinois, United States; [email protected] , (United States)
  • 7 New York City Department of Health and Mental Hygiene, 5939, New York, New York, United States; [email protected] , (United States)
  • 8 Los Angeles County Department of Public Health, 5147, Los Angeles, California, United States; [email protected] , (United States)
  • 9 Los Angeles County Department of Public Health, 5147, Los Angeles, California, United States; [email protected] , (United States)
  • 10 New York City Department of Health and Mental Hygiene, 5939, New York, New York, United States; [email protected] , (United States)
  • 11 University of California San Diego, Medicine, 9500 Gilman Drive MC 0711, La Jolla, California, United States, 92093; [email protected] , (United States)
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Dec 21, 2020
Identifiers
DOI: 10.1089/AID.2020.0145
PMID: 33349132
Source
Medline
Language
English
License
Unknown

Abstract

An important component underlying the disparity in HIV risk between race/ ethnic groups is the preferential transmission between individuals in the same group. We sought to quantify transmission between different race/ethnicity groups and measure racial assortativity in HIV transmission networks in major metropolitan areas in the United States. We reconstructed HIV molecular transmission networks from viral sequences collected as part of HIV surveillance in New York City, Los Angeles County, and Cook County, Illinois. We calculated assortativity (the tendency for individuals to link to others with similar characteristics) across the network for three candidate characteristics: transmission risk, age at diagnosis, and race/ethnicity. We then compared assortativity between race/ethnicity groups. Finally, for each race/ethnicity pair, we performed network permutations to test whether the number of links observed differed from that expected if individuals were sorting at random. Transmission networks in all three jurisdictions were more assortative by race/ethnicity than by transmission risk or age at diagnosis. Despite the different race/ethnicity proportions in each metropolitan area and lower proportions of clustering among African Americans than other race/ethnicities, African Americans were the group most likely to have transmission partners of the same race/ethnicity. This high level of assortativity should be considered in the design of HIV intervention and prevention strategies. .

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